| Publication | 
Definition | 
CIS (%) | 
BMS (%) | 
RRMS (%) | 
SPMS (%) | 
Diagnosis | 
Duration of illness in years (SD) | 
EDSS score (SD) | 
Disease modif. hist. use (%) | 
Disease modif. curr. use (%) | 
Steroids hist. use (%) | 
Steroids curr. use (%) | 
 
| 
Audoin 2006...
 | 
Individuals with relapse-remitting multiple sclerosis | 
0 (0%) | 
0 (0%) | 
21 (100%) | 
0 (0%) | 
Clinical, EDSS and MSFC | 
4.20 | 
2.00 | 
N/A | 
7 (33%) | 
N/A | 
0 (0%) |  
| 
Audoin 2010...
 | 
Individuals with clinically isolated syndrome suggestive of multiple sclerosis | 
62 (100%) | 
0 (0%) | 
0 (0%) | 
0 (0%) | 
Clinical and EDSS | 
0.30 | 
1.00 | 
0 (0%) | 
0 (0%) | 
N/A | 
0 (0%) |  
| 
Ceccarelli 2...
 | 
Individuals with benign multiple sclerosis | 
0 (0%) | 
19 (100%) | 
0 (0%) | 
0 (0%) | 
Clinical and EDSS | 
20.00 | 
2.00 | 
N/A | 
9 (47%) | 
N/A | 
0 (0%) |  
| 
Ceccarelli 2...
 | 
Individuals with relapse-remitting multiple sclerosis | 
0 (0%) | 
0 (0%) | 
15 (100%) | 
0 (0%) | 
Clinical and EDSS | 
6.00 | 
1.50 | 
N/A | 
15 (100%) | 
N/A | 
0 (0%) |  
| 
Ceccarelli 2...
 | 
Individuals with clinically isolated syndrome suggestive of multiple sclerosis | 
28 (100%) | 
0 (0%) | 
0 (0%) | 
0 (0%) | 
Clinical | 
N/A | 
N/A | 
0 (0%) | 
0 (0%) | 
0 (0%) | 
0 (0%) |  
| 
Duan 2012...
 | 
Individuals with relapse-remitting multiple sclerosis | 
0 (0%) | 
0 (0%) | 
26 (100%) | 
0 (0%) | 
EDSS and McDonald criteria | 
3.77 | 
3.00 | 
N/A | 
0 (0%) | 
N/A | 
0 (0%) |  
| 
Henry 2008...
 | 
Individuals with clinically isolated syndrome suggestive of multiple sclerosis | 
41 (100%) | 
0 (0%) | 
0 (0%) | 
0 (0%) | 
Clinical, EDSS and MSFC | 
0.37 (0.25) | 
1.10 (0.80) | 
0 (0%) | 
0 (0%) | 
N/A | 
0 (0%) |  
| 
Mesaros 2008...
 | 
Individuals with benign multiple sclerosis | 
0 (0%) | 
60 (100%) | 
0 (0%) | 
0 (0%) | 
Clinical and EDSS | 
22.70 | 
1.50 | 
N/A | 
20 (33%) | 
N/A | 
0 (0%) |  
| 
Mesaros 2008...
 | 
Individuals with relapse-remitting multiple sclerosis | 
0 (0%) | 
0 (0%) | 
28 (100%) | 
0 (0%) | 
Clinical and EDSS | 
3.00 | 
1.00 | 
N/A | 
21 (75%) | 
N/A | 
0 (0%) |  
| 
Morgen 2006...
 | 
Individuals with relapse-remitting multiple sclerosis | 
0 (0%) | 
0 (0%) | 
19 (100%) | 
0 (0%) | 
EDSS and McDonald criteria | 
N/A | 
1.00 | 
0 (0%) | 
0 (0%) | 
N/A | 
0 (0%) |  
| 
Prakash 2010...
 | 
Individuals with relapse-remitting multiple sclerosis | 
0 (0%) | 
0 (0%) | 
21 (100%) | 
0 (0%) | 
EDSS and Poser criteria | 
7.30 (0.10) | 
2.20 | 
N/A | 
N/A | 
N/A | 
N/A |  
| 
Prinster 200...
 | 
Individuals with relapse-remitting multiple sclerosis | 
0 (0%) | 
0 (0%) | 
51 (100%) | 
0 (0%) | 
EDSS and Poser criteria | 
13.10 (6.40) | 
2.60 | 
0 (0%) | 
0 (0%) | 
N/A | 
0 (0%) |  
| 
Prinster 201...
 | 
Individuals with relapse-remitting multiple sclerosis | 
0 (0%) | 
0 (0%) | 
128 (100%) | 
0 (0%) | 
EDSS and Poser criteria | 
10.14 (7.20) | 
2.80 | 
0 (0%) | 
115 (90%) | 
N/A | 
0 (0%) |  
| 
Raz 2010...
 | 
Individuals with clinically isolated syndrome suggestive of multiple sclerosis | 
34 (100%) | 
0 (0%) | 
0 (0%) | 
0 (0%) | 
Clinical and EDSS | 
N/A | 
1.50 | 
N/A | 
N/A | 
0 (0%) | 
0 (0%) |  
| 
Riccitelli 2...
 | 
Individuals with relapse-remitting multiple sclerosis and fatigue | 
0 (0%) | 
0 (0%) | 
10 (100%) | 
0 (0%) | 
Clinical, EDSS and FSS | 
8.20 (6.20) | 
1.50 | 
N/A | 
0 (0%) | 
N/A | 
0 (0%) |  
| 
Riccitelli 2...
 | 
Individuals with relapse-remitting multiple sclerosis but no fatigue | 
0 (0%) | 
0 (0%) | 
14 (100%) | 
0 (0%) | 
Clinical, EDSS and FSS | 
10.60 (6.60) | 
1.50 | 
N/A | 
0 (0%) | 
N/A | 
0 (0%) |  
| 
Riccitelli 2...
 | 
Individuals with relapse-remitting multiple sclerosis | 
0 (0%) | 
0 (0%) | 
78 (100%) | 
0 (0%) | 
Clinical and EDSS | 
9.60 | 
1.50 | 
N/A | 
70 (90%) | 
N/A | 
0 (0%) |  
| 
Spano 2010...
 | 
Individuals with benign multiple sclerosis | 
0 (0%) | 
10 (100%) | 
0 (0%) | 
0 (0%) | 
EDSS and McDonald criteria | 
17.10 (4.50) | 
1.75 | 
N/A | 
10 (100%) | 
N/A | 
0 (0%) |