| Publication | 
Definition | 
Modulation | 
Whole brain volume control | 
Covariation for age | 
Covariation for sex | 
 
| 
Audoin 2006...
 | 
VBM in individuals with relapse-remitting multiple sclerosis | 
No | 
No | 
No | 
No |  
| 
Audoin 2010...
 | 
VBM in individuals with clinically isolated syndrome suggestive of multiple sclerosis | 
Yes | 
No | 
No | 
No |  
| 
Ceccarelli 2...
 | 
VBM in individuals with benign multiple sclerosis | 
Yes | 
Covariation for intracranial volume | 
Yes | 
Yes |  
| 
Ceccarelli 2...
 | 
VBM in individuals with relapse-remitting multiple sclerosis | 
Yes | 
Covariation for intracranial volume | 
Yes | 
Yes |  
| 
Ceccarelli 2...
 | 
VBM in individuals with clinically isolated syndrome suggestive of multiple sclerosis | 
Yes | 
Covariation for intracranial volume | 
Yes | 
Yes |  
| 
Duan 2012...
 | 
VBM in individuals with relapse-remitting multiple sclerosis | 
Yes | 
Covariation for intracranial volume | 
No | 
Yes |  
| 
Henry 2008...
 | 
VBM in individuals with clinically isolated syndrome suggestive of multiple sclerosis | 
Yes | 
Covariation for intracranial volume | 
Yes | 
Yes |  
| 
Mesaros 2008...
 | 
VBM in individuals with benign multiple sclerosis | 
Yes | 
Covariation for intracranial volume | 
Yes | 
Yes |  
| 
Mesaros 2008...
 | 
VBM in individuals with relapse-remitting multiple sclerosis | 
Yes | 
Covariation for intracranial volume | 
Yes | 
Yes |  
| 
Morgen 2006...
 | 
VBM in individuals with relapse-remitting multiple sclerosis | 
Yes | 
No | 
No | 
No |  
| 
Prakash 2010...
 | 
VBM in individuals with relapse-remitting multiple sclerosis | 
Yes | 
Covariation for intracranial volume | 
Yes | 
Yes |  
| 
Prinster 200...
 | 
VBM in individuals with relapse-remitting multiple sclerosis | 
Yes | 
Covariation for intracranial volume | 
Yes | 
Yes |  
| 
Prinster 201...
 | 
VBM in individuals with relapse-remitting multiple sclerosis | 
Yes | 
Covariation for intracranial volume | 
Yes | 
Yes |  
| 
Raz 2010...
 | 
VBM in individuals with clinically isolated syndrome suggestive of multiple sclerosis | 
Yes | 
Covariation for intracranial volume | 
No | 
No |  
| 
Riccitelli 2...
 | 
VBM in individuals with relapse-remitting multiple sclerosis and fatigue | 
Yes | 
Covariation for intracranial volume | 
Yes | 
Yes |  
| 
Riccitelli 2...
 | 
VBM in individuals with relapse-remitting multiple sclerosis but no fatigue | 
Yes | 
Covariation for intracranial volume | 
Yes | 
Yes |  
| 
Riccitelli 2...
 | 
VBM in individuals with relapse-remitting multiple sclerosis | 
Yes | 
Normalization to intracranial volume | 
Yes | 
Yes |  
| 
Spano 2010...
 | 
VBM in individuals with benign multiple sclerosis | 
Yes | 
Covariation for intracranial volume | 
No | 
No |